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Electropollution as a Possible Explanation for Climate Change. - Dragonfly Kingdom Library

Posted on July 26, 2021 at 8:35 AM Comments comments ()

Abstract

 

The basic premise of this article is that human generated electromagnetic radiation is contributing to global warming. It may do so by diverting an energy force termed KELEA (kinetic energy limiting electrostatic attraction) from its presumed association with cosmic rays. Cosmic ray delivered KELEA is viewed as normally participating in the formation of cloud condensation nuclei (CCN). It may do so by transforming electrostatically inert particles into electrostatic aerosols capable of acting as CCN. The resulting clouds act as a reflective barrier to some of the infrared radiation from the sun and, thereby, reduce the earth’s heat. This article proposes that increasing levels of electromagnetic radiation in the atmosphere is reducing the capacity of cosmic rays to deliver adequate KELEA to maintain climate stability through optimal cloud formation. Specifically, the fluctuating electrical fields accompanying electromagnetic radiation may do so by competitively withdrawing some of the KELEA from the incoming cosmic rays. Previously described studies by Dr. Wilhelm Reich attributed to an energy force termed orgone, are consistent with weather activity being inducible using a device that likely delivers KELEA to the atmosphere. In addition to the foregoing consideration, there are many agricultural and industrial applications of KELEA activated fluids that can reduce carbon emissions. It is important that the scope of climate science be broadened to include a detailed understanding of KELEA and of its many potential practical applications in addressing global warming



Indexed for SCIRP by Dragonfly Kingdom Library




Oxidative Stress Associated with SARS-Cov-2 (COVID-19). - Dragonfly Kingdom Library

Posted on July 24, 2021 at 11:45 AM Comments comments ()

 

1Department of Cellular and Molecular Biology, El-Oued University, Algeria

 

2Laboratory of Biodiversity and Application of Biotechnology in the Agricultural Field, Faculty of Natural Sciences and Life, University of El Oued, Algeria



Abstract

COVID-19 patients have a higher risk of developing inflammatory responses associated with serious and even fatal respiratory diseases. This review focuses on the relationship between oxidative stress and COVID-19. Coronaviruses are a family of common RNA viruses that can cause serious lower respiratory tract infections, followed by bronchitis and pneumonia. Pulmonary inflammation, fever and fibrosis are symptoms of COVID-19 mediated by cytokine pro-inflammatory.


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Oxidative stress affect repair mechanisms and the immune control system, which is one of the main events of the inflammatory response which allows us also to conclude that oxidative stress is a major factor increasing the severity of COVID-19 especially during chronic diseases associated with the fragility of the antioxidant system, suggesting to recommend antioxidants supplementation in therapeutic strategies against COVID-19....


Indexed for ClinMed by Dragonfly Kingdom Library

https://www.clinmedjournals.org/articles/jide/journal-of-infectious-diseases-and-epidemiology-jide-6-121.php?jid=jide


Quarantine during COVID-19 outbreak: Changes in diet and physical activity increase the risk of cardiovascular disease

Posted on July 21, 2021 at 5:00 AM Comments comments ()

Abstract

Aims: CoV-19/SARS-CoV-2 is a highly pathogenic virus that is causing a global pandemic with a high number of deaths and infected people. To contain the diffusion of infection, several governments have enforced restrictions on outdoor activities or even collective quarantine on the population. The present commentary briefly analyzes the effects of quarantine on lifestyle, including nutrition and physical activity and the impact of new technologies in dealing with this situation.


 

Data synthesis: Quarantine is associated with stress and depression leading to unhealthy diet and reduced physical activity. A diet poor in fruit and vegetables is frequent during isolation, with a consequent low intake of antioxidants and vitamins. However, vitamins have recently been identified as a principal weapon in the fight against the Cov-19 virus. Some reports suggest that Vitamin D could exert a protective effect on such infection. During quarantine, strategies to further increase home-based physical activity and to encourage adherence to a healthy diet should be implemented. The WHO has just released guidance for people in self-quarantine, those without any symptoms or diagnosis of acute respiratory illness, which provides practical advice on how to stay active and reduce sedentary behavior while at home.

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Conclusion: Quarantine carries some long-term effects on cardiovascular disease, mainly related to unhealthy lifestyle and anxiety. Following quarantine, a global action supporting healthy diet and physical activity is mandatory to encourage people to return to a good lifestyle routine.

 

Keywords: COVID-19; Gender; Lifestyle; Physical activity; Quarantine; Stress; Vitamin D. 


Indexed for NIH Pubmed by Dragonfly Kingdom Library


https://pubmed.ncbi.nlm.nih.gov/32571612/

Increased sugar consumption and a lack of physical exercise as possible determinants of COVID-19 disease severity. - Dragonfly Kingdom Library/Underground Intelligence Muscle & Fitness

Posted on July 21, 2021 at 4:55 AM Comments comments ()

Abstract

We present a hypothesis for increased sugar consumption and a lack of physical exercise as possible determinants of COVID-19 disease severity by impaired glucose metabolism, concurring into a syndemic. National data demonstrate that increased sugar consumption, a high daily caloric intake, and low levels of daily physical activity are independently associated with COVID-19 mortality. Further, genetic factors such as variations in the androgen receptor may compound the effects of an unhealthy lifestyle and increase the risk of severe COVID-19 symptoms in some patients. A diet high in sugar in combination with a low level of physical activity may increase blood glucose levels and impair glucose metabolism.




Recent data show that patients admitted to the hospital with high levels of fasting blood glucose are at an increased risk for severe COVID-19 symptoms. Moreover, elevated glucose levels resulted in increased SARS-CoV-2 viral loads in vitro. We believe that healthier habits of diet and exercise, by improving glucose homeostasis could modulate the individual risk of severe COVID-19 symptoms 


Indexed for NIH Pubmed by Dragonfly Kingdom Library


https://pubmed.ncbi.nlm.nih.gov/33529978/



Western Diet and the Immune System: An Inflammatory Connection. - Dragonfly Kingdom Library/Underground Intelligence Muscle & Fitness

Posted on July 21, 2021 at 12:20 AM Comments comments ()

Abstract

The consumption of Western-type calorically rich diets combined with chronic overnutrition and a sedentary lifestyle in Western societies evokes a state of chronic metabolic inflammation, termed metaflammation. Metaflammation contributes to the development of many prevalent non-communicable diseases (NCDs), and these lifestyle-associated pathologies represent a rising public health problem with global epidemic dimensions.

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A better understanding of how modern lifestyle and Western diet (WD) activate immune cells is essential for the development of efficient preventive and therapeutic strategies for common NCDs. Here, we review the current mechanistic understanding of how the Western lifestyle can induce metaflammation, and we discuss how this knowledge can be translated to protect the public from the health burden associated with their selected lifestyle.


Indexed for NIH Pubmed by Dragonfly Kingdom Library


https://pubmed.ncbi.nlm.nih.gov/31747581/

Findings of Graphene Oxide in Vaccines Raises Eyebrows Causing a Second Look at the "Magnet Challenge". In other news, Vitamin C Reduces Graphene Oxide. - Dragonfly Kingdom Library

Posted on June 30, 2021 at 6:40 AM Comments comments ()

Reduction of graphene oxide vial-ascorbic acid†

Jiali Zhang,a Haijun Yang,a Guangxia Shen,a Ping Cheng,a Jingyan Zhang*b and Shouwu Guo*a


Abstract

We demonstrated that the individual graphene oxide sheets can be readily reduced under a mild condition using L-ascorbic acid (L-AA). This simple approach should find practical applications in large scale production of water soluble graphene.

The potential contributing role of stealth virus infections in children presenting with behavioral problems needs to be addressed. - Dragonfly Kingdom Library

Posted on June 16, 2021 at 12:20 AM Comments comments ()

An infectious illness, attributed to atypically structured cytopathic "stealth" viruses, occurred in 1996 in the Mohave Valley region of the United States. A stealth virus-infected child from this region has developed a severe noninflammatory, vacuolating (spongiform) en cephalopathy. The illness initially presented as a behavioral problem without overt neurological signs. Extensive investigations, including repeated magnetic resonance imaging, two brain biopsies, and stealth virus cultures, have helped define the disease process occurring in this child. Significant clinical benefit with apparent retardation of disease progression occurred during a 6-week course of ganciclovir therapy. The potential contributing role of stealth virus infections in children presenting with behavioral problems needs to be addressed.




Indexed for Europe PMC by Dragonfly Kingdom Library 


 https://europepmc.org/article/MED/10331961

Chronic Fatigue Syndrome (CFS): An Imprecisely Defined Infectious Disease Caused by Stealth Adapted Viruses. - Dragonfly Kingdom Library

Posted on June 16, 2021 at 12:05 AM Comments comments ()

Chronic Fatigue Syndrome (CFS): An Imprecisely Defined Infectious Disease Caused by Stealth Adapted Viruses

W John Martin*

Institute of Progressive Medicine, South Pasadena, USA

 

Introduction

Much of the research on the chronic fatigue syndrome (CFS) is misguided for two major reasons. First, it is falsely assumed that CFS is a distinct, definable illness, which can be reliably differentiated from other neurological and psychiatric illnesses. Second, in spite of compelling evidence to the contrary, CFS is not generally regarded as an infectious illness. This review addresses these two issues and is followed by a brief discussion on stealth adapted viruses and the alternative cellular energy (ACE) pathway.

 

Diagnosis

It is clearly inappropriate that the diagnosis of CFS is being applied to severely ill, bedridden patients, as well as to outspoken, internet savvy individuals who frequently attend conferences and other public events. The core symptom for the majority of those diagnosed with CFS is a feeling of not having sufficient physical and/or mental capacity to undertake ordinary tasks, with no clear explanation as to why this limitation exists. The frustrating feeling of persisting fatigue will typically become exacerbated, with a delayed onset after even modest physical and/or mental exertion and can remain so for several days, without being relieved by sleep. Beyond the core symptom of unexplained fatigue, there are a plethora of additional clinical manifestations. To a varying extent, different CFS patients experience mental confusion with a lack of clarity in their thoughts (brain fog); inability to stay focused on a topic (attention deficit); poor memory, even forgetting the names of common everyday items; and emotional lability, expressed as periods of sadness (lack of joy); and occasionally as anxiety, anger and/or depression. CFS patients can often experience hypersensitivity to sensory inputs, leading to pain, paresthesia, photophobia, tinnitus and chemical sensitivity. The autonomic nervous system may show signs of dysregulation such as postural hypotension with tachycardia; other disorders affecting blood circulation; irritable bowel; etc. The severity of these various symptoms differs widely among patients diagnosed with CFS and can also vary markedly over time in the same individual. Unless further defined, the CFS diagnosis is largely uninformative with regards to a particular patient's illness. Furthermore, similar sets of symptoms can be present in patients with traumatic brain injuries and in patients in whom additional symptoms or laboratory test results can lead to a better defined neurological, psychiatric, or autoimmune diagnosis. Based on more questionable criteria, some patients who would otherwise be diagnosed as mild to moderate CFS are diagnosed as having depression, personality disorder, burnout, post-traumatic stress, fibromyalgia, chronic Lyme disease, Gulf War syndrome, chronic inflammatory response syndrome (CIRS), chemical sensitivity, electromagnetic sensitivity, irritable bowel syndrome, etc. According to some definitions, CFS is excluded if the patient has psychiatric symptoms, yet other definitions allow for co-morbid psychiatric diagnoses [1-6].

 

Several laboratory tests will commonly yield results in CFS patients, which are different from those in most healthy controls [7-26]. The items being tested are only loosely directed to the element of chronic fatigue. Moreover, similar abnormal results can occur in association with many other chronic illnesses in which fatigue is not a predominant feature. Emotional stress and prolonged periods of physical inactivity can potentially cause disruptions in the biochemical pathways measured in some of these assays. It has also been argued that knowing that one has an abnormal test result will simply add to further pessimism about being ill. Certain individuals seem to do better by consciously disregarding the illness concept and are more accepting of their physical and mental limitations. The diagnosis of CFS for these patients is considered counterproductive.



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Infection

Multiple lines of evidence indicate an infectious cause of CFS. The first is the occurrence of major outbreaks of CFS-related illnesses. Seventy-three outbreaks occurring between 1934 and 1990 are listed in the book The Clinical and Scientific Basis of Myalgic Encephalomyelitis - Chronic Fatigue Syndrome, edited by Dr. Byron Hyde [27]. Prominent among these outbreaks was an illness beginning in 1985 and first publicly reported in 1986, which occurred in the Lake Tahoe/Incline Village region of Nevada [28]. Two of the many unpublicized subsequent outbreaks in the US are worth noting. Dr. Donovan Anderson manages a general medical practice in Mohave Valley, Arizona, which is nearby to Needles, California. In the spring of 1996, he became aware of an acute illness which progressively affected well over a hundred of the local residents. Individuals presented with acute gastrointestinal symptoms, developing approximately a week after contact with someone with similar symptoms. Vomiting, diarrhea and abdominal pain would resolve within 1-2 weeks. Rather than the individuals regaining their prior health, most progressed to a chronic illness. This illness was characterized by severe fatigue, cognitive impairments and mood disorders [29]. The disease affecting most of these individuals was confirmed as CFS by a visiting specialist in this condition. Several patients had very severe illnesses, including dementia. A veterinarian exhibited symptoms of acute depression prior to suicide. An 8-year-old child of a symptomatic mother exhibited attention deficit hyperactivity disorder (ADHD) in second grade. He mentioned to his mother that he would see double when tired or stressed. An MRI of his brain showed fairly extensive white matter disease suggestive of a leukodystrophy, with frontal lobe predominance. A brain biopsy of the frontal lobe showed no inflammation. Rather it was pathologically described as a spongy (vacuolar) myelinopathy [30]. Based on a positive stealth virus culture (to be discussed in a later section of this article), the child was prescribed a course of ganciclovir, which provided some temporary clinical improvements. Nevertheless, he continued to deteriorate, became physically incapacitated and died approximately one-year later. Blood samples from over 50 additional patients involved in this outbreak were also cultured for evidence of infection with stealth adapted viruses. All of the tested samples gave strongly positive results. Most of the patients have remained chronically ill for over 20 years with many now being diagnosed as having fibromyalgia in addition to CFS.


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A hairdresser in Joelton, TN, realized she, her two staff members, and a number of her clients were experiencing episodes of pain that mainly affected areas of their skin, along with a feeling of general malaise and noticeably impaired thought processing. She communicated her concerns to the local health authority and to the Centers for Disease Control and Prevention (CDC). The representative from the CDC asked if she knew of additional patients. The hairdresser took the initiative of describing her illness in the local Shopper magazine. Well over 100 people from the local community responded that they were experiencing similar symptoms. As soon as the issue of a potential infectious process arose, the local health authority, on the advice from CDC, refused to engage in any further contact. This patient and several of her close associates tested positive in stealth adapted virus cultures...... 


Indexed for Journal Of Infectious Diseases & Epidemiology by Dragonfly Kingdom Library  

https://www.clinmedjournals.org/articles/jide/journal-of-infectious-diseases-and-epidemiology-jide-6-106.php?jid=jide



These findings support the concepts that stealth viruses can account for a spectrum of dysfunctional brain diseases. - Dragonfly Kingdom Library

Posted on June 15, 2021 at 11:30 AM Comments comments ()

Abstract

A cytopathic 'stealth' virus was cultured from the cerebrospinal fluid of a patient with a bipolar psychotic disorder who developed a severe encephalopathy leading to a vegetative state. DNA sequencing of a polymerase chain reaction-amplified product from infected cultures has identified the virus as an African green monkey simian cytomegalovirus (SCMV)-related stealth virus. The virus is similar to the SCMV-related stealth virus isolated from a patient with chronic fatigue syndrome. The findings support the concepts that stealth viruses can account for a spectrum of dysfunctional brain diseases and that some of these viruses may have arisen from live polio viral vaccines.


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Indexed for NIH Pubmed by Dragonfly Kingdom Library


https://pubmed.ncbi.nlm.nih.gov/8888270/

Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. - Dragonfly Kingdom Library

Posted on June 15, 2021 at 11:15 AM Comments comments ()

Abstract

Background: The authors have previously reported genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) based on expression of 88 human genes.

 

Aim: To attempt to reproduce these findings, determine the specificity of this signature to CFS/ME, and test for associations between CFS/ME subtype and infection.

 

Methods: Expression levels of 88 human genes were determined in blood of 62 new patients with idiopathic CFS/ME (according to Fukuda criteria), six patients with Q-fever-associated CFS/ME from the Birmingham Q-fever outbreak (according to Fukuda criteria), 14 patients with endogenous depression (according to DSM-IV criteria) and 29 normal blood donors.


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Results: In patients with CFS/ME, differential expression was confirmed for all 88 genes. Q-CFS/ME had similar patterns of gene expression to idiopathic CFS/ME. Gene expression in patients with endogenous depression was similar to that in the normal controls, except for upregulation of five genes (APP, CREBBP, GNAS, PDCD2 and PDCD6). Clustering of combined gene data in CFS/ME patients for this and the authors' previous study (117 CFS/ME patients) revealed genomic subtypes with distinct differences in SF36 scores, clinical phenotypes, severity and geographical distribution. Antibody testing for Epstein-Barr virus, enterovirus, Coxiella burnetii and parvovirus B19 revealed evidence of subtype-specific relationships for Epstein-Barr virus and enterovirus, the two most common infectious triggers of CFS/ME.

 

Conclusions: This study confirms the involvement of these genes in CFS/ME 


Indexed for NIH Pubmed by Dragonfly Kingdom Library 


https://pubmed.ncbi.nlm.nih.gov/19955554/



In some cases of violence and other criminal behavior, this can be a consequence of central nervous system infection. - Dragonfly Kingdom Library

Posted on June 15, 2021 at 10:55 AM Comments comments ()

Abstract

Infections of the central nervous system can damage the brain and cause abnormal behavior. In this article, the authors examine how behavior is affected by damage to different parts of the brain. They then focus on damage caused by specific infections of the brain and how these can result in abnormal behavior with legal consequences.


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Examples of such infections include neurosyphilis, encephalitis lethargica, herpes simplex encephalitis, and various other viral encephalitides, both acute and chronic. The AIDS dementia complex, which results from HIV infection of the brain, causes behavioral abnormalities in addition to motor and cognitive impairments. In some cases of violence and other criminal behavior, this can be a consequence of central nervous system infection, and the authors suggest that criminal sanctions in such events are inappropriate in the absence of volitional criminal intent.



Indexed for NIH Pubmed by Dragonfly Kingdom Library 


https://pubmed.ncbi.nlm.nih.gov/14584527/

Mainstream neurologists and psychiatrists have largely refrained from serious consideration of a virus cause of common brain diseases. This article exposes a weakness in this argument by describing the process of stealth adaptation of viruses. - Dra

Posted on June 15, 2021 at 10:35 AM Comments comments ()


eISSN: 2373-6410

 

Neurology & Stroke

 

 


 

Stealth Adapted Viruses – Possible Drivers of Major Neuropsychiatric Illnesses Including Alzheimer’s Disease

W John Martin

Institute of Progressive Medicine, South Pasadena, USA

 

Correspondence: W John Martin, Institute of Progressive Medicine, 1634 Spruce Street, South Pasadena, CA 913, USA, Tel 626-616-2868

 

Received: May 22, 2015 | Published: June 22, 2015

 

Citation: Martin WJ (2015) Stealth Adapted Viruses – Possible Drivers of Major Neuropsychiatric Illnesses Including Alzheimer’s Disease. J Neurol Stroke 2(3): 00057. DOI: 10.15406/jnsk.2015.02.00057

 


 

Abstract

Mainstream neurologists and psychiatrists have largely refrained from serious consideration of a virus cause of common brain diseases. This is mainly because of the general lack of any accompanying immune system stimulated inflammatory reaction within the brain. This article exposes a weakness in this argument by describing the process of “stealth adaptation” of viruses. Deletion or mutation of relatively few virus components can result in derivative viruses, which are no longer effectively recognized by the cellular immune system. Consequently, there is no triggering of the inflammatory response. Furthermore, the brain is uniquely susceptible to symptomatic illness caused by stealth adapted viruses. An understanding of stealth adaptation greatly expands the potential scope of viral illnesses. It also underscores the value of using virus cultures as a diagnostic tool and of taking appropriate measures to avoid transmission of infection. More importantly, therapeutic measures are available for suppressing both stealth adapted and conventional virus infections through enhancement of the alternative cellular energy (ACE) pathway. Such measures are available for clinical evaluation in treating many of the major illnesses affecting the brain, including Alzheimer’s disease.

 

Keywords: Alzheimer’s disease; Neurology; Psychiatry; Cellular immunity; Immune evasion; Inflammation; Alternative cellular energy; ACE; Stealth adapted viruses; Herpes simplex virus; HSV; EnerceuticalsTM; KELEA; CFS; Chronic fatigue syndrome; Dementia; Encephalopathy

 

Abbreviations:

KELEA: Kinetic Energy Limiting Electrostatic Attraction; ACE: Alternative Cellular Energy; CFS: Chronic Fatigue Syndrome; CPE: Cytopathic Effect; HSV: Herpes Simplex Virus; SCMV: African Green Monkey Simian Cytomegalovirus; HCMV: Human Cytomegalovirus; CTL: Cytotoxic T Lymphocytes; CSF: Cerebrospinal Fluid; CPE: Cytopathic Effect; ALS: Amyotrophic Lateral Sclerosis; ACE: Alternative Cellular Energy; UV: Ultraviolet; ICE: Insufficiency of Cellular Energy 



Introduction

With the possible exception of cancer, diseases of the brain comprise most of the worst feared human aliments. Whether it is the increasing likelihood of autism occurring in children [1]; or Alzheimer’s disease occurring in the elderly [2], the current medical paradigms are failing to provide effective answers. Nor has significant progress been made in addressing many other tragic illnesses, such as schizophrenia, bipolar psychosis, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Society is further challenged by a range of somewhat less severe but still disabling illnesses, including chronic fatigue syndrome (CFS), fibromyalgia, depression, drug addiction, criminal behaviors and intellectual impairments affecting both learning and work performances.

 

Various investigators have suggested a possible infectious origin of several of the aforementioned neuropsychiatric illnesses [3-11]. Because of the absence of noticeable inflammation, however, it is usually argued that if infectious agents are indeed involved, their effects must be indirect and quite possibly delayed. For example, common infections occurring during pregnancy can clearly lead to elevated levels of various cytokines as part of the immune response. There are supporting data that maternal cytokines may significantly inhibit normal fetal brain development, with potential later life consequences [12-14]. Other researchers have suggested that certain infectious agents might potentially trigger the production of antibodies, which cross-react with neuronal components, thereby interfering with normal brain function. Such self-reacting antibodies may continue to form as part of an ongoing autoimmune process [15-17]. None of these scenarios envisions viruses as the direct cause of ongoing cellular injury...........


Indexed for Medcrave by Dragonfly Kingdom Library

https://medcraveonline.com/JNSK/stealth-adapted-viruses-ndash-possible-drivers-of-major-neuropsychiatric-illnesses-including-alzheimerrsquos-disease.html

HERV-W ENV was highly expressed in the leukocytes of COVID-19 patients but not in those of healthy donors. - Dragonfly Kingdom Library

Posted on June 15, 2021 at 9:50 AM Comments comments ()

 

 

Abstract

Background

Despite an impressive effort in clinical research, no standard therapeutic approach for coronavirus disease 2019 (COVID-19) patients has been established, highlighting the need to identify early biomarkers for predicting disease progression and new therapeutic interventions for patient management. The present study aimed to evaluate the involvement of the human endogenous retrovirus -W envelope (HERV-W ENV) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection considering recent findings that HERVs are activated in response to infectious agents and lead to various immunopathological effects. We analysed HERV-W ENV expression in blood cells of COVID-19 patients in correlation with clinical characteristics and have discussed its potential role in the outcome of the disease.

Methods

We analysed HERV-W ENV expression in blood samples of COVID-19 patients and healthy donors by flow cytometry and quantitative reverse transcriptase PCR analysis, and evaluated its correlation with clinical signs, inflammatory markers, cytokine expression, and disease progression.





 

Findings

HERV-W ENV was highly expressed in the leukocytes of COVID-19 patients but not in those of healthy donors. Its expression correlated with the markers of T-cell differentiation and exhaustion and blood cytokine levels. The percentage of HERV-W ENV-positive lymphocytes correlated with inflammatory markers and pneumonia severity in COVID-19 patients. Notably, HERV-W ENV expression reflects the respiratory outcome of patients during hospitalization.

Interpretation

Given the known immuno- and neuro-pathogenicity of HERV-W ENV protein, it could promote certain pathogenic features of COVID-19 and therefore serve as a biomarker to predict clinical progression of disease and open to further studies for therapeutic intervention.



Indexed for The Lancet by Dragonfly Kingdom Library 


https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00134-1/fulltext

Origins of Life? Study Shows Adding UV Light Helps Form 'Missing G' of RNA Building Blocks. - Dragonfly Kingdom Library

Posted on June 13, 2021 at 11:40 AM Comments comments ()



For scientists attempting to understand how the building blocks of RNA originated on Earth, guanine has proven to be a particular challenge. By adding UV light to a model prebiotic reaction, researchers have discovered a route by which guanine could have been formed.



https://www.nsf.gov/news/news_summ.jsp?cntn_id=117226

Imbalance of a positive charge: Structurally Observed Electrostatic Features of the COVID-19 Coronavirus-Related Experimental Structures inside Protein Data Bank: A Brief Update. - Dragonfly Kingdom Library

Posted on June 13, 2021 at 8:30 AM Comments comments ()

Since the Coronavirus disease (COVID-19) outbreak at the end of 2019, the past two month has seen an acceleration both in and outside China in the R&D of the diagnostics, vaccines and therapeutics for this novel coronavirus. As one of the molecular forces that determine protein structure, electrostatic effects dominate many aspects of protein behaviour and biological function. Thus, incorporating currently available experimental structures related to COVID-19, this article reports a simple python-based analysis tool and a LaTeX-based editing tool to extract and summarize the electrostatic features from experimentally determined structures, to strengthen our understanding of COVID-19's structure and function and to facilitate machine-learning and structure-based computational design of its neutralizing antibodies and/or small molecule(s) as potential therapeutic candidates. Finally, this article puts forward a brief update of the structurally observed electrostatic features of the COVID-19 coronavirus


Li, W. Structurally Observed Electrostatic Features of the COVID-19 Coronavirus-Related Experimental Structures inside Protein Data Bank: A Brief Update. Preprints 2020, 2020030081 (doi: 10.20944/preprints202003.0081.v1).


...........

The charged amino acids in the spike protein of SARS-CoV-2 exhibit some specific distribution. In the RBD region of the S1 unit the positive charge dominates in the protein interior and the negative charge prevails on the surface exposed towards ACE2 receptor. The charged amino acids in the S2 region preceding heptad repeats of the spike protein of SARS-CoV-2, exhibit a central concentration, and the imbalance of a positive charge. The idea that both distributions of charged amino acids may, in an electrostatic manner, facilitate the coronavirus infection of the cell is presented. An evaluation of the virus-receptor binding energy, by docking the peptide resembling the human receptor site to the virus RBD, and the estimation of electromechanical deformation of the cell membrane by S2 during the prefusion process were included. Possible prevention of viral infection is suggested.

Keywords: coronavirus, COVID-19, SARS-CoV-2, fusion, amino acids, electric field, charge, electrostatic potential, anions, vitamin C


Government data shows rising OOP spending for consumers, but excludes some types of health-related items and services that add significantly to the total amount and consumer share of spending. Examples include nutritional supplements and complementary

Posted on June 8, 2021 at 8:35 AM Comments comments ()

Government data shows rising OOP spending for

consumers, but excludes some types of health-related items

and services that add significantly to the total amount and

consumer share of spending. Examples include nutritional

supplements and complementary and alternative medicine.



https://www2.deloitte.com/content/dam/Deloitte/us/Documents/life-sciences-health-care/us-lchs-dig-deep-hidden-costs-112414.pdf

Integrative medicine to tackle the problem of chronic diseases. - Dragonfly Kingdom Library/Bright Star Apothecary Complimentary Integrative Alternative Medicine/Underground Intelligence Muscle & Fitness

Posted on June 8, 2021 at 8:00 AM Comments comments ()


Rustum Roy



Abstract


This article summarizes important ways that integrative medicine can contribute to resolving the global health crisis with special reference to the US. Research using modern methods of analysis of cellular changes at the epigenetic level has shown that diet and lifestyle interventions greatly improve the state of patients’ health. Estimates have been given that up to 75% of all US health costs can be saved by these methods, particularly if applied preventatively. It is thus vital that active steps are taken to implement such programs, to reduce costs to citizens and society alike, as well as to Government.

Keywords: Chronic disease, diet, epigenetics, health care crisis, integrative medicine, lifestyle





INTRODUCTION


It is almost proverbial to state that, with almost 20% of the average citizen's life spent chronically ill, the American dream is now marred by poor quality of life in old age. At the cost of enormous research efforts in many countries in the last 50 years, medical science has won major extensions of lifespan, but these are all but negated by the failure to tackle the chronic disease problem.[1–5] The prospect of spending an average 16 years out of a four score year life expectancy in pain and misery is not pleasant to say the least. Several questions come to mind. How can the human misery involved be averted, or at least diminished? How can its costs be reduced – both for citizens and society, for the individual and for the state? Can anyone concerned with human suffering doubt America's need to enfranchise all its citizens into adequate healthcare?

The Institute of Medicine (IOM)[6] states that ‘Across the world, improving health is not merely an academic exercise; it is of the utmost importance. We seek to make a real difference in the world by providing advice to decision makers’.[7] It believes that its work can make a significant impact on the health of not just the US, but the whole world. Earlier this year, in conjunction with the Bravewell Collaborative, the IOM hosted a ‘Summit on Integrative Medicine and the Health of the Public’.[8] A recent article in the Wall Street Journal declared that ‘This (meeting) is a watershed in the evolution of integrative medicine, a holistic approach to healthcare that uses the best of conventional and alternative therapies such as meditation, yoga, acupuncture and herbal remedies. Many of these therapies are now scientifically documented to be not only medically effective but also cost effective.’[9]

In the US, the coauthor of ‘Critical: What We Can Do About the Health Care Crisis’[10] former Senate Majority Leader Tom Daschle, in concert with President Barack Obama, has stated that ‘To make affordable healthcare available to the 45 million Americans without health insurance, we must address fundamental causes of health and illness, and provide incentives for healthy ways of living rather than reimbursing only drugs and surgery’.[11] Their declaration points the way to a new approach to healthcare involving prevention, rather than waiting for the individual to fall sick.

President Obama's election campaign Health Plan[12] openly acknowledged that the US is suffering a huge chronic disease epidemic. In proposing a preventive medicine remedy for the crisis, it emphasized, ‘An increasing number of Americans are suffering and dying needlessly from diseases such as obesity, diabetes, heart disease, asthma and HIV/AIDS, all of which can be delayed in onset if not prevented entirely’.[13]

Roughly three quarters of U.S. healthcare costs arise from five of the most costly diseases. A high proportion of that 75% is now known to be preventable by changes in diet and lifestyle, respectively, known in Ayurveda as Ahara and Vihara. Key papers by Professor Dean Ornish, Clinical Professor of Medicine at the University of California, San Francisco (UCSF), and founding President of its Preventive Medicine Research Institute have shown this to be true.[14,15]

SCIENCE OF DIET AND LIFESTYLE INTERVENTIONS
To impact the progress of chronic disease, Ayurveda has long held that specific stressors at the root of degenerative processes driving its progress must be identified and removed. It maintains that, once this is done, our bodies’ remarkable capacity to begin healing will begin to take effect. The studies by Ornish[14,15] specifically support this thesis, which is also supported by other research.[16–18] An intriguing question from the perspective of western science is why this should be possible. Allopathic medicine tends to propagate the viewpoint that the only hope for cure of a condition lies in a drug intervention.

If there is now substantial evidence to the contrary (or at least the beginnings of it), it is time to ask such questions as, ‘How, in scientific terms, could this be possible?’ ‘How can the physical body, left to itself in optimal circumstances, eliminate pathology without external assistance?’ ‘What could make the circumstances optimal?’ ‘What kinds of disease, and what levels of pathology can be treated by such means?’

While it is beyond the scope of this article to answer such questions fully, it is clear that they must be considered fundamental to the scientific investigation of Integrative Medicine – because in its simplest and earliest definition, Integrative Medicine was simply described as a system of medicine, which regarded the whole person, including body, mind and spirit, to be of fundamental importance; that neglect of this fact does patients substantial damage and can even have a nocebo effect; and because of this, pathology responds better when a Holistic approach is taken, and people are treated as persons, rather than as biochemical machines.




The fact of spontaneous recovery is well known. The placebo effect is now one of the best established effects known to modern scientific medicine – because all random control trials are placebo controlled. Integrative medicine recognizes this, and ensures that patients have the benefit of a placebo effect that they are surely entitled to expect, rather than it being negated for some reason.

The fact that spontaneous recovery is possible is well understood, and certain aspects of how to induce it and negate it. Recent scientific studies[14–17] indicate that it works far more rapidly than previously imagined. But to promote it most effectively, lifestyle factors that have provoked the development of a patient's chronic condition MUST be addressed. The body's natural healing abilities, activated in the placebo effect, can then be promoted. These studies indicate, therefore, that our health and well-being can be vastly improved by integrative medicine. Observing these rules will make significant differences to the power of any therapy, increasing the rapidity with which its influences are felt......


Indexed for NIH by Dragonfly Kingdom Library