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Protective effect of vitamin C against the ethanol mediated toxic effects on human brain glial cells. - Dragonfly Kingdom Library

Posted on September 14, 2021 at 9:10 AM Comments comments (0)

Abstract

It is now known that chronic consumption of excessive amounts of alcohol is a major source of social and medical problems. Ethanol-mediated glial cell activation may lead to neuron damage in many ways, including the formation of free radicals and production of pro-inflammatory molecules. Vitamin C (vit-C) is an essential dietary nutrient required as a co-factor for many enzymes and a very efficient antioxidant, protecting cells against free radical-mediated damage. The objective of this study was to evaluate the protective effects of vit-C on glial cell activation and viability against ethanol-mediated toxicity. Human brain astrocyte cells (HA) were exposed to ethanol (0, 50, and 350 mmol/L) for 24 h. We found that glial cells incubated with different concentrations of vit-C increase their vit-C in a dose-dependent manner. HA incubated with 0, 50 or 350 mmol/L of ethanol for up to 24 h showed toxic effects that were proportional to the levels of ethanol in the medium, HA showed increased levels of heat shock protein (Hsp70). However, cells enriched with vit-C before being exposed to ethanol, were better protected against the alcohol-mediated toxicity than non-supplemented cells, and showed significantly lower concentrations of Hsp70. Ethanol also caused increased expression of cyclooxygenase-2 (COX-2) and synthesis of prostaglandin E2 (PGE2), which were reduced by vit-C. In summary, HA supplemented with vit-C were significantly more resistant to the ethanol-mediated toxic effects.


Indexed for NIH Pubmed by Dragonfly Kingdom Library 

https://pubmed.ncbi.nlm.nih.gov/14559112/

Butterbur root extract and music therapy in the prevention of childhood migraine. - Dragonfly Kingdom Library

Posted on September 10, 2021 at 9:20 AM Comments comments (0)

Abstract

Background: Migraine is very common in school-aged children, but despite a number of pharmacological and non-pharmacological options for prophylaxis, randomized controlled evidence in children is small. Evidence-based prophylactic drugs may have considerable side effects.

 

Objective: This study was to assess efficacy of a butterbur root extract (Petadolex) and music therapy in primary school children with migraine.

 

Design: Prospective, randomized, partly double-blind, placebo-controlled, parallel-group trial.

 

Methods: Following a 8-week baseline patients were randomized and received either butterbur root extract (n=19), music therapy (n=20) or placebo (n=19) over 12 weeks. All participants received additionally headache education ("treatment as usual") from the baseline onwards. Reduction of headache frequency after treatment (8-week post-treatment) as well as 6 months later (8-week follow-up) was the efficacy variable.

 

Results: Data analysis of subjects completing the respective study phase showed that during post-treatment, only music therapy was superior to placebo (p=0.005), whereas in the follow-up period both music therapy and butterbur root extract were superior to placebo (p=0.018 and p=0.044, respectively). All groups showed a substantial reduction of attack frequency already during baseline.

 

Conclusion: Butterbur root extract and music therapy might be superior to placebo and may represent promising treatment approaches in the prophylaxis of paediatric migraine.....


Indexed for NIH Pubmed by Dragonfly Kingdom Library 


https://pubmed.ncbi.nlm.nih.gov/17659990/

Migraine as an inflammatory disorder | Neurology. - Dragonfly Kingdom Library

Posted on September 10, 2021 at 9:15 AM Comments comments (0)

Migraine as an inflammatory disorder

Christian Waeber, Michael A. Moskowitz


First published May 23, 2005, DOI: https://doi.org/10.1212/WNL.64.10_suppl_2.S9



 

 

Inflammation is a localized response designed to protect tissues against infection, injury, or disease. The inflammatory response acts to destroy, dilute, or wall off (sequester) both the injurious agent and the injured area. The production and release of chemical agents by cells in the affected tissue result in the four well-known signs of Celsus: pain (dolor), heat (calor), redness (rubor), and swelling (tumor), to which Galen later added loss of function (functio laesa). Histologically, inflammation is characterized by a complex series of events. These include the following: dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the inflammatory focus.

 

Although pain and inflammation usually go hand in hand, migraine has not classically been considered an inflammatory disease, possibly because it is not obviously associated with heat, redness, and swelling. Instead, a vascular etiology was proposed on the basis of a report that ergotamine tartrate alleviates pain and reduces the amplitude of temporal artery pulsation in migraineurs,1 a small but significantly increased risk for strokes,2 association with vascular malformations,3 and genetic disorders such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).4 For most of the twentieth century, the prevailing theory of migraine held that pain results from an abnormal dilatation of intracranial blood vessels, leading to mechanical excitation of sensory fibers that innervate these vessels. This “vascular” theory, however, has never been validated. No differences in blood flow velocity exist in vertebral and middle cerebral arteries during and outside migraine attacks,5 and a consistent relationship between vessel caliber, cerebral blood flow, and headache has not been established.6

 

In recent years, accumulating evidence has shifted the emphasis away from vascular smooth muscle and toward mechanisms related to inflammation within cephalic.......


https://n.neurology.org/content/64/10_suppl_2/S9.short

Anti-Inflammatory Diet in Clinical Practice: A Review. - Dragonfly Kingdom Library

Posted on September 10, 2021 at 9:05 AM Comments comments (0)

Abstract

Recently, there has been an increase in the research regarding the impact of acute and chronic inflammation on health and disease. Specific foods are now known to exert strong effects on inflammatory pathways within the body. Carefully selecting foods that are anti-inflammatory in nature while avoiding foods that are proinflammatory is central to an anti-inflammatory diet plan. Ultimately, the plan models a pattern of eating that (1) focuses on eating whole, plant-based foods that are rich in healthy fats and phytonutrients and (2) maintains a stable glycemic response.



 

Keywords: Mediterranean diet; anti-inflammatory diet; fatty acids; glycemic index; nutrition therapy 



Indexed for NIH Pubmed by Dragonfly Kingdom Library


https://pubmed.ncbi.nlm.nih.gov/28350517/





An aberrant inflammatory response in severe COVID-19. - Dragonfly Kingdom Library

Posted on September 10, 2021 at 8:45 AM Comments comments (0)

Abstract

Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immunity, discuss potential mechanisms underlying pathological responses, and highlight important areas for basic research on this topic.

 

Main text

The substantial mortality in coronavirus disease 2019 (COVID-19) has been driven largely by an absence of pre-existing immunity that could have provided some protection in vulnerable populations against severe and fatal outcomes. As population immunity increases in some regions, severe COVID-19 has become much less frequent; yet communities lacking protection continue to be ravaged by this disease. In addition to vaccines, having medications that prevent the acute respiratory distress syndrome (ARDS) that is often central in fatal COVID-19 could dramatically reduce the threat of SARS-CoV-2 as a human pathogen. For this reason, understanding mechanisms involved in the pathogenesis of severe COVID-19 is imperative.

 

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections result in a vast spectrum of clinical outcomes, yet most infections are subclinical or mild, even in the absence of pre-existing immunity. The drivers of severe COVID-19 are not entirely clear, but excessive inflammation is nearly always associated with worsening clinical status in this disease. Interestingly, minimal virus is detected in most organs obtained from autopsies of COVID-19 patients, which may suggest that while the virus triggers an initial disease, it is not the ultimate cause of organ failure. Tissue damage often appears driven by excessive accumulation and activation of effector immune cells. Together, the evidence supports a model in which severe and fatal COVID-19 are driven by an aberrant immune response to the infection that causes pathology rather than restoring health. We propose that this aberrant response is the driver of susceptibility to severe COVID-19 in vulnerable populations.

 

In addition to severe disease, SARS-CoV-2 infections can result in long-term symptoms (here called “long COVID syndromes”) in a large proportion of cases, regardless of severity of the acute infection. Many of the long-term sequelae are likely to be driven by inflammatory pathways. In this article, we outline clinical presentations of COVID-19 that are likely driven by dysregulated host immune responses and discuss potential mechanisms of disease as well as outstanding clinical and research questions on this important topic.

 

COVID-19 clinical presentations and syndromes related to inflammation

Severe acute COVID-19 Those who develop severe COVID-19 usually worsen after 7 days of mild-to-moderate symptoms. Many of the sequalae in severe cases, such as ARDS, thromboembolism, arrhythmias, and renal failure, are mediated by inflammation and are central in the mortality associated with COVID-19. Some effective treatments have immunomodulatory or immunosuppressive effects. These include compounds with data showing clinical benefit such as corticosteroids, tocilizumab that inhibits the proinflammatory cytokine interleukin-6 (IL-6), the JAK inhibitor baricitinib, and SARS-CoV-2 monoclonal antibodies (mAbs). While we know that severe COVID-19 is associated with an elevation in routine inflammatory markers and an absence of early neutralizing antibodies, we currently lack adequate tools to identify cases that would benefit from early therapeutic interventions. Further, methods are not yet established for guiding treatments based on monitoring of inflammation within affected organs, short of invasive biopsies. As an example, the assessment of lung bronchoscopy fluid for cellular and soluble factors could be very helpful for therapeutic monitoring and potentially for guiding treatment, yet practical methods for dynamic sampling of this fluid and studies correlating results with clinical outcomes are not available. Such methods could also improve our understanding of the mechanisms resulting in long-term sequelae of severe COVID-19.

Multisystem inflammatory syndrome in children/adolescence.......


Indexed for NIH by Dragonfly Kingdom Library


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279571/

Choose your favorite track for your playlists & music library. - Underground Intelligence Music & Multimedia

Posted on September 10, 2021 at 7:45 AM Comments comments (0)



A wide variety of Music for Playlist Curators & Personal Playlists 


or choose your favorite music streaming platform at https://songwhip.com/natureyogimarcoandre


Bonus tracks ( Podcast )



 
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This review suggests that yoga can be a viable intervention to reduce inflammation across a multitude of chronic conditions. - Dragonfly Kingdom Library

Posted on September 8, 2021 at 12:10 AM Comments comments (0)

Abstract

Background:

Many chronic conditions, including heart disease, cancer, and rheumatoid arthritis, are associated with underlying chronic inflammatory processes. Literature reviews have analyzed a variety of integrative therapies and their relationships with chronic inflammation. This systematic review is unique in reporting solely on yoga’s relationship with inflammation. Its purpose was to synthesize current literature examining the impact of yoga interventions on inflammatory biomarkers in adults with chronic inflammatory–related disorders.

 

Method:

Searches of several electronic databases were conducted. Inclusion criteria were (a) English language, (b) sample age >18 years old, (c) yoga interventions involving postures with or without yoga breathing and/or meditation, and (d) measured inflammatory biomarkers.

 

Results:

The final review included 15 primary studies. Of these, seven were rated as excellent and eight as average or fair. There was considerable variability in yoga types, components, frequency, session length, intervention duration, and intensity. The most common biomarkers measured were interleukin-6 (n = 11), C-reactive protein (n = 10), and tumor necrosis factor (n = 8). Most studies reported positive effects on inflammatory biomarkers (n = 11) from baseline to post yoga intervention. Analysis of the dose showed higher total dose (>1,000 min) resulted in greater improvements in inflammation.

 

Conclusion:

This review suggests that yoga can be a viable intervention to reduce inflammation across a multitude of chronic conditions. Future studies with detailed descriptions of yoga interventions, measurement of new and well-established inflammatory biomarkers, and larger sample sizes are warranted to advance the science and corroborate results.

 

Keywords: yoga, inflammation, biomarkers, review, chronic conditions...... 


Indexed for NIH by Dragonfly Kingdom Library


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700894/

Does reactivation of cytomegalovirus contribute to severe COVID-19 disease? Latent human cytomegalovirus (CMV) is carried by 70-90% of the adult population and is reactivated by inflammation. - Dragonfly Kingdom Library

Posted on September 7, 2021 at 11:20 AM Comments comments (0)

Abstract

The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?

 

Key points

Latent human cytomegalovirus (CMV) is carried by 70–90 % of the adult population and is reactivated by inflammation. One third of patients in intensive care reactivate CMV, which doubles their mortality rate; how many COVID-19 patients reactivate latent CMV to complicate their diseases and enhance their mortality rate?........


 

Indexed for Biomed Central by Dragonfly Kingdom Library 


https://immunityageing.biomedcentral.com/articles/10.1186/s12979-021-00218-z

Risk of Forming Stealth Adapted Coronaviruses with Covid-19 Vaccines. Analogy with Stealth Adapted Monkey Cytomegaloviruses Resulting from the Use of Polio Vaccines. - Dragonfly Kingdom Library

Posted on September 7, 2021 at 10:55 AM Comments comments (2)

Risk of Forming Stealth Adapted Coronaviruses

with Covid-19 Vaccines. Analogy with Stealth
Adapted Monkey Cytomegaloviruses Resulting
from the Use of Polio Vaccines 

Stealth adaptation is a virus immune evasion/escape mechanism that comprises the deletion or
mutation of the viral genes, which code for components targeted by cellular immunity. It can also require
the incorporation of additional genetic sequences to regain the capacity for replication and transmission.
Stealth adapted viruses typically cause noninflammatory infections, which are particularly symptomatic
when they involve the brain. Stealth adaptation has occurred with cytomegalovirus contaminants of
polio vaccines produced in kidney cell cultures of rhesus and African green monkeys. Two aspects of the
current Covid-19 vaccines are conducive to the formation of stealth adapted SARS-CoV-2 coronaviruses.
These are the relative ineffectiveness of intramuscular injections in stimulating fully effective respiratory
mucosal immunity, and the inclusion of only a single virus component as the immunogen, namely the
spike protein. Stealth adapted coronaviruses will have the potential to cause chronic, non-inflammatory
brain illnesses similar to those being caused by stealth adapted monkey cytomegaloviruses. These include
the chronic fatigue syndrome (CFS) and autism. The long Covid syndrome has many features in common
with CFS and the affected patients need to be evaluated for stealth adapted virus infections. With regards
to potential therapy, the body has a non-immunological anti-virus defense mechanism that is mediated by
the alternative cellular energy (ACE) pathway. Enhancing the ACE pathway, especially in those susceptible
to severe Covid-19 illness and in those who are experiencing the long Covid syndrome, is preferable to
having to repeatedly vaccinate mankind against evolving variants of the SARS-CoV-2 virus. Furthermore,
immunization is not indicated in those who are already infected with the stealth adapted coronavirus.
Optimizing ACE pathway-based therapies will also have benefits in treating other stealth adapted virus
brain diseases including CFS and autism.
Keywords: Stealth adapted viruses; SARS-CoV-2; Covid-19; Long COVID syndrome; Chronic fatigue
syndrome; Polio vaccine
Abbreviations: ACE: Alternative Cellular Energy; CFS: Chronic Fatigue Syndrome; CTL: Cytotoxic T
Lymphocyte

Viruses can undergo an immune evasion/escape mechanism termed stealth adaptation
[1,2]. It comprises the deletion or mutation of the genes coding for the relatively few virus
components that are normally targeted by the cellular immune system. There is also the
acquisition of sufficient additional genetic sequences from cellular and/or other microbial
genomes to enable virus replication and transmission [3,4]. Stealth adaptation is envisioned
as a generic process that can occur with all viruses. It has most notably occurred with the
cytomegalovirus of African green monkeys [5,6]. Cultured kidney cells from cytomegalovirus
infected monkeys were and are still used to produce polio vaccines [7,8]. The brain is
particularly susceptible to symptomatic illness caused by stealth adapted viruses [9-11]. This
is because of the complex spatial arrangements and networking pathways in the brain. Diverse
functional disorders can, therefore, result from even limited, localized areas of cellular damage
in the brain. In most other organs limited localized cellular damage is easily compensated by
an increase in activity elsewhere in the same organ. The absence of inflammation caused by
stealth adapted viruses and their genetic diversity and instability have hindered mainstream
virologists from identifying stealth adapted viruses as the underlying and/or contributing cause of such as the common brain illnesses, such as the chronic
fatigue syndrome (CFS), amyotrophic lateral sclerosis, bipolar
psychosis, Alzheimer’s disease, and autism [12-15]. Stealth adapted
viruses causing these medical conditions are best detected using
appropriate virus cultures followed by genetic sequencing.
Public Health authorities have shied away from acknowledging
the existence of monkey-derived stealth adapted viruses. This is in
spite of a 1972 joint study by the Food and Drug Administration
(FDA) and the polio vaccine manufacturer. Kidney cell cultures
from eleven African green monkeys were held aside from polio
vaccine production. All eleven cultures subsequently tested
positive for African green monkey simian cytomegalovirus (SCMV).
Moreover, the viruses from four of the eleven cultures were atypical
in not being easily identified as SCMV using the then standard
virus detection method. The FDA decision to not publicly disclose
such findings was felt justified because there had been no reports
of acute cytomegalovirus illnesses in polio vaccine recipients
(personal communication). The unequivocal description in 1995
of an SCMV-derived stealth adapted virus from a CFS patient [6]
was further resisted by the FDA, CDC, and NIH. This was, in part,
due to the inferred possibility that the testing of cytomegalovirus
contaminated experimental polio vaccines in African chimpanzees
could have led to the development of HIV and, therefore, be
responsible for the AIDS epidemic [16]. Public Health indifference
and complacency remained in spite of my reporting of positive virus
cultures from a child with austism, an adult with bipolar psychosis,
and numerous patients wit severe encephalopathies. Conversely, a
2002 study showing positive cultures in some blood donors led to
the official declaration that the testing for stealth adapted viruses
had put the Nation’s health in “Immediate Jeopardy.” I was clinically
prohibited from further patient testing for stealth adapted viruses.
In my opinion, the NIH and FDA are making a comparable error
with their prompting the widespread use of the current Covid-19
vaccines. Had they taken a more constructive position regarding
stealth adaptation.
Public Health authorities would have learned that the body is
not totally dependent upon the immune system to suppress virus
infections. Thus, even though the cellular immune system does not
effectively engage with stealth adapted viruses, infected. patients
and virus inoculated animals do recover without inflammation
[17]. Cellular repair is also demonstrable in virus cultures [2,18].
The recovery is mediated by the alternative cellular energy (ACE)
pathway, a non-food source of chemical and electrical energy
[2,19]. The ACE pathway is expressed as an increased non-thermal
kinetic activity of the body’s fluids. Water with a heightened level
of this energy can potentially be used to enhance the ACE pathway
[2,19,20]. Experimental protocols applicable to acute Covid-19
illness and the long Covid syndrome include the inhalation of
nebulized water and the continuing wearing of sealed pouches
containing 50-100 ml of the water, respectively. These protocols
are broadly applicable to infections by all types of stealth adapted
viruses and the viruses from which they are derived........

Setting a New Standard for Purity: Toniiq at Bright Star Apothecary. - Underground Intelligence Muscle & Fitness at Dragonfly Kingdom International Service Agency

Posted on September 4, 2021 at 10:25 AM Comments comments (0)



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Each Batch is Individually Tested - We test each batch both ourselves and through a third-party independent laboratory to ensure our ingredients contain the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities to ensure the highest level of quality




Enhancing the Alternative Cellular Energy (ACE) Pathway with KELEA Activated Water as Therapy for Infectious Diseases. - Dragonfly Kingdom Library

Posted on August 25, 2021 at 6:05 AM Comments comments (0)

Abstract

Many infectious diseases have yet to be conquered by modern medicine. This is generally attributed to both a failure of the immune system and the lack of an effective anti-microbial pharmaceutical. Infections can be regarded as a competitive process between the microbe and the host for cellular energy-generated resources. Cells obtain energy not only from the metabolism of food but also from the alternative cellular energy (ACE) pathway. This pathway utilizes an environmental force termed as KELEA (kinetic energy limiting electrostatic attraction), which provides an added kinetic/chemical energy to the body's fluids. The ACE pathway can be enhanced through the use of KELEA activated water, which is currently available under different names from several sources. Enhancing the body's ACE pathway, including the use of a wearable waterceutical ™, provides a novel means of potentially increasing the body's resistance against all infectious diseases.

 

Keywords: ACE pathway; Alternative cellular energy; KELEA activated water; stealth adapted viruses; waterceutical.

 

Indexed for NIH Pubmed by Dragonfly Kingdom Library


https://pubmed.ncbi.nlm.nih.gov/32066365/

Nature & Human Health: Enhanced immune functioning emerges as one promising candidate for a central pathway between nature and health. - Dragonfly Kingdom Library

Posted on August 25, 2021 at 6:00 AM Comments comments (0)

Abstract

How might contact with nature promote human health? Myriad studies have linked the two; at this time the task of identifying the mechanisms underlying this link is paramount. This article offers: (1) a compilation of plausible pathways between nature and health; (2) criteria for identifying a possible central pathway; and (3) one promising candidate for a central pathway. The 21 pathways identified here include environmental factors, physiological and psychological states, and behaviors or conditions, each of which has been empirically tied to nature and has implications for specific physical and mental health outcomes. While each is likely to contribute to nature’s impacts on health to some degree and under some circumstances, this paper explores the possibility of a central pathway by proposing criteria for identifying such a pathway and illustrating their use. A particular pathway is more likely to be central if it can account for the size of nature’s impacts on health, account for nature’s specific health outcomes, and subsume other pathways. By these criteria, enhanced immune functioning emerges as one promising candidate for a central pathway between nature and health. There may be others.

 

Keywords: natural environment, greenspace, immune, mechanism, mental health, literature review

Introduction

Contact with nature has been tied to health in a plenitude of studies. Time spent in and around tree-lined streets, gardens, parks, and forested and agricultural lands is consistently linked to objective, long-term health outcomes. The less green a person’s surroundings, the higher their risk of morbidity and mortality – even when controlling for socioeconomic status and other possible confounding variables. The range of specific health outcomes tied to nature is startling, including depression and anxiety disorder, diabetes mellitus, attention deficit/hyperactivity disorder (ADHD), various infectious diseases, cancer, healing from surgery, obesity, birth outcomes, cardiovascular disease, musculoskeletal complaints, migraines, respiratory disease, and others, reviewed below. Finally, neighborhood greenness has been consistently tied to life expectancy and all-cause mortality........


Indexed for NIH by Dragonfly Kingdom Library


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548093/