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The role of lectins in allergic sensitization and allergic disease

Posted on January 21, 2023 at 9:40 AM


The role of lectins in allergic sensitization and allergic disease

Fabián Salazar, Herb F Sewell, Farouk Shakib, Amir M Ghaemmaghami

PMID: 23534971 DOI: 10.1016/j.jaci.2013.02.001


Abstract

Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding of the molecular basis of this group of chronic inflammatory disorders remains rather elusive. Recently, the role of carbohydrates on allergens and their counterstructures on antigen-presenting cells (lectins) have been highlighted as crucial factors in allergen sensitization, which culminates in TH2 cell differentiation and the production of deleterious specific IgE antibodies. Here we review recent progress on the role of different lectins in patients with type I hypersensitivity or allergy, their interplay with other determinants of allergenicity, and ways of developing therapeutic modalities against newly identified targets.

Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

Indexed for NIH PubMed by Dragonfly Kingdom Library



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