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Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?. -- Dragonfly Kingdom Library

Posted on December 4, 2020 at 5:50 PM

Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?

Mirko Baglivo 1, Manuela Baronio 2, Giuseppe Natalini 3, Tommaso Beccari 4, Pietro Chiurazzi 5, Ezio Fulcheri 6, Paolo Pietro Petralia 7, Sandro Michelini 8, Giovanni Fiorentini 9, Giacinto Abele Miggiano 10, Assunta Morresi 11, Gerolamo Tonini 12, Matteo Bertelli 13

Affiliations expand

PMID: 32191676 PMCID: PMC7569585 DOI: 10.23750/abm.v91i1.9402

Free PMC article

Abstract

Background: Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.

 

Methods and results: We focus on the role of lipid structures, such as lipid rafts and cholesterol, involved in the process, mediated by endocytosis, by which viruses attach to and infect cells. Previous studies have shown that many naturally derived substances, such as cyclodextrin and sterols, could reduce the infectivity of many types of viruses, including the coronavirus family, through interference with lipid-dependent attachment to human host cells.

 

Conclusions: Certain molecules prove able to reduce the infectivity of some coronaviruses, possibly by inhibiting viral lipid-dependent attachment to host cells. More research into these molecules and methods would be worthwhile as it could provide insights the mechanism of transmission of SARS-COV-2 and, into how they could become a basis for new antiviral strategies.   https://pubmed.ncbi.nlm.nih.gov/32191676/

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