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A new category of pathogenic components, normally dormant within human genomes, has been identified

Posted on December 27, 2021 at 3:05 AM
A new category of pathogenic components, normally dormant within human genomes, has been identified


Abstract


The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained elusive. A new category of pathogenic components, normally dormant within human genomes, has been identified: human endogenous retroviruses (HERVs). These represent ∼8% of the human genome, and environmental factors have reproducibly been shown to trigger their expression. The resulting production of envelope (Env) proteins from HERV-W and HERV-K appears to engage pathophysiological pathways leading to the pathognomonic features of MS and ALS, respectively. Pathogenic HERV elements may thus provide a missing link in understanding these complex diseases. Moreover, their neutralization may represent a promising strategy to establish novel and more powerful therapeutic approaches.


Indexed for NIH Pubmed by Dragonfly Kingdom Library 

 

https://pubmed.ncbi.nlm.nih.gov/29551251/

Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved 





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