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Honeybee venom can cure breast cancer, study finds

Posted on April 6, 2022 at 9:30 AM



The cancer community is buzzing over a new study that says venom from bees can kill cancer cells.


Scientists at the Harry Perkins Institute of Medical Research in Western Australia tested venom from more than 300 honeybees and bumblebees against two types of aggressive, hard to treat breast cancer: triple negative and human epidermal growth factor receptor 2 (HER2) enriched. They found that a compound in the venom called melittin could destroy breast cancer cells within an hour, without causing harm to other cells. They also found that when used in conjunction with chemotherapy drugs, the melittin helped formed pores in the cancer cell membrane which could potentially allow therapies to better penetrate the cells........ 



Abstract


Despite decades of study, the molecular mechanisms and selectivity of the biomolecular components of honeybee (Apis mellifera) venom as anticancer agents remain largely unknown. Here, we demonstrate that honeybee venom and its major component melittin potently induce cell death, particularly in the aggressive triple-negative and HER2-enriched breast cancer subtypes. Honeybee venom and melittin suppress the activation of EGFR and HER2 by interfering with the phosphorylation of these receptors in the plasma membrane of breast carcinoma cells...... https://www.nature.com/articles/s41698-020-00129-0




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